The aim of this work is to investigate the effect of thermal treatment on the grinding behavior of manganese ore in the various size fractions of -1.7+1.18, -1.18+0.6, -0.6+0.3 and -0.3+ 0.15 mm. Breakage Function Determination Software (BFDS) is used to calculate the selection function of the experiment. The results of SEM analysis show the micro-cracks in the thermally treated manganese sample, and DTA/TG analysis show that heating at 750 °C leads to dehydroxylation of montmorillonite, and decomposition of calcite and decomposition of montmorillonite to silicate minerals occur at 850 °C. Montmorillonite mineral with a hardness of 2 is turned into silicate minerals with an average hardness of 7. Therefore, it can be seen that the thermal treatment leads to a decrease in the specific rate of breakage from 1.04 min-1 to 0.65 min-1 (approximately to 37%) for a size fraction of -0.300+ 0.15 mm. It; can be expressed that the thermally treated sample is broken more slowly than the untreated sample. Also, parameter “A” is the maximum Si value, decreasing for the heated sample from 4.36 min-1 to 4.28 min-1. The selection function results show that all size fractions of this material follow a first-order kinetics.