Dynamic slope stability in open-pit mines still remains a challenging task in the computational mining design. Earthquake and blasting are two significant sources of dynamic loads that can cause many damages to open-pit mines in active seismic areas and during exploitation cycles. In this work, the effects of earthquake and blasting on the stability of the NW slope of Chadormalu mine are compared by a numerical modeling method. The dynamic results show that the maximum displacement under earthquake and blasting loads within the slope are 844 mm and 146 mm, respectively. According to the shear strain results, both the earthquake and blasting waveforms are destructive, while the earthquake waveforms cause more damages to the slope. Moreover, the deterministic and probabilistic seismic hazard analyses are carried out to assess the seismicity of the mine area. The experimental results indicate that the maximum values for the vertical and horizontal accelerations are 0.55 g and 0.75 g, respectively. The maximum calculated acceleration is then scaled to the selected earthquake accelerograms. In order to show the effective impact of the established scale, the model is executed using the original accelerograms. The results obtained show that the established scale prevents overestimation and underestimation of the displacement and strain. Therefore, applying scaled accelerograms in a dynamic slope stability analysis in mine slopes leads to more reliable and robust results. The overall results show that a strong earthquake causes plenty of damages to the slope, and consequently, interrupts the mining cycle. Hence, the seismic study and dynamic slope stability should be considered as a part of the computational mining design.