Use of nanotechnology has proven to be a promising approach toward remediation of all phases of environment. The aim of this work is to investigate the effects of different parameters on using iron III oxide nanoparticles in a continuous flow configuration for the removal of Cd2+ ionsfrom contaminated soils. Also selective sequential extraction tests are carried out to evaluate the nanoparticle tendency to remove cadmium from different fractions of soils. In order to achieve this goal, a specific flow rate of a nanoparticle solution was passed through a soil sample in a column with 3 cm diameter and 4 cm height. Up to 100% of cadmium removal was achieved by providing a nano-fluid concentration of 500 ppm, pH of 6.5, treatment duration of 24 hours, and flow rate of 0.5 mL/min. Evaluation of the results obtained showed that the tendency of the iron oxide nanoparticles to remove cadmium from different fractions of contaminated soil was in the order of exchangeable > carbonates > oxides and hydroxides > organic matter > residual. The results obtained from this work can be used to develop an appropriate remediation protocol for contaminated soils.