This paper presents a quantitative modeling for delineating alteration zones in the hypogene zone of the Miduk porphyry copper deposit (SE Iran) based on the core drilling data. The main goal of this work was to apply the Ordinary Kriging (OK), Artificial Neural Networks (ANNs), and Concentration-Volume (C-V) fractal modelings on Cu grades to separate different alteration zones. Anisotropy was investigated and modeled based on calculating the experimental semi-variograms of Cu value, and then the main variography directions were identified and evaluated. The block model of Cu grade was generated using the kriging and ANN modelings followed by log-log plots of the C-V fractal modeling to determine the Cu threshold values used in delineating the alteration zones. Based on the correlation between the geological models and the results derived via C-V fractal modeling, Cu values less than 0.479% resulting from kriging modeling had more overlapped voxels with the phyllic alteration zone by an overall accuracy (OA) of 0.83. The spatial correlation between the potassic alteration zone in a 3D geological model and the high concentration zones in the C-V fractal model showed that Cu values between 0.479% and 1.023%, resulting from kriging modeling, had the best overall accuracy (0.78). Finally, based on the correlation between classes in the binary geological and fractal models of the hypogene zone, this research work showed that kriging modeling could delineate the phyllic (with lower grades) and potassic (with higher grades) alteration zones more effectively compared with ANNs.