Bedrock unconfined compressive strength (UCS) is a key parameter in designing thegeosciences and building related projects comprising both the underground and surface rock structures. Determination of rock UCS using standard laboratory tests is a complicated, expensive, and time-consuming process, which requires fresh core specimens. However, preparing fresh cores is not always possible, especially during the drilling operation in cracked, fractured, and weak rocks. Therefore, some attempts have recently been made to develop the indirect methods, i.e. intelligent predictive models for rock UCS estimation, which require no core preparation and laboratory equipment. This work focuses on the application of new combinations of intelligent techniques including adoptive neuro-fuzzy inference system (ANFIS), genetic algorithm (GA), and particle swarm optimization (PSO) in order to predict rock UCS. These models were constructed based on the collected laboratory datasets upon 93 core specimens ranging from weak to very strong rock types. The proposed hybrid model results were compared with each other, and the real data and multiple regression (MR) results. These comparisons were made using coefficient of correlation, mean of square error, mean of absolute error, and variance account for indices. The comparison results proved that the ANFIS-GA combination had a relatively higher accuracy than the ANFIS-PSO combination, and both had a higher capability than the MR model. Furthermore, the ANFIS-GA and ANFIS-PSO model results were completely in accordance with the UCS laboratory test, and they were more accurate than the previous single/hybrid intelligent models. Lastly, a parametric study of the suggested models showed that the density and Schmidt hammer rebound had the highest influence, and porosity had the lowest influence on the output (UCS).